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Formulation, Development, and Evaluation of Herbal Effervescent Mouthwash Tablet Containing Azadirachta Indica (Neem) and Curcumin for the Maintenance of Oral Hygiene

[ Vol. 14 , Issue. 2 ]


Mankaran Singh, Deepak Sharma*, Dinesh Kumar, Gurmeet Singh, Gaurav Swami and Mahendra Singh Rathore   Pages 145 - 161 ( 17 )


Background: Dental caries originate due to the localized dissolution of the hard tissues of teeth, mainly caused by acids, developed by the presence of microorganisms in the biofilm (dental plaque) on the surface of teeth causing “cavities”. Commercially available liquid mouthwashes containing synthetic active ingredients possess limitations like teeth staining, higher alcoholic content, taste disturbances, xerostomia, and stability issues.

Objective: To make the solid preparation for oral hygiene (US6428770B1) in the form of herbal effervescent mouthwash tablet (CN106619318A, US8728446B2) using Azadirachta indica and Curcumin having antimicrobial, antibacterial, antiplaque, and anti-inflammatory activity.

Methods: The optimization study of effervescent granules was performed by 33 factorial design. A total of 27 preliminary experimental batches were prepared by the fusion method, varying the amount of citric acid, tartaric acid, and sodium bicarbonate. A complex of curcumin was prepared with hydroxyl propyl β-cyclodextrin and further examined by scanning electron microscopy. The prepared tablets were evaluated for pre and post-compression parameters. The in vitro antimicrobial study was performed by Agar well diffusion method against S. mutans.

Results: All the experimental batches of effervescent granules were evaluated for pH, effervescent time, and CO2 content. Six batches were further selected for final tablet preparation. The results of the pre-compression parameters revealed excellent flow properties and post-compression parameters; the results were also significant. The antimicrobial study revealed the F3 as a final best formulation.

Conclusion: The developed herbal formulation (F3) has a good potential to maintain oral hygiene as compared to alcoholic mouthwash and further studies may be necessary to confirm the efficacy of the formulation since only a single bacterial strain was assayed.


Dental caries, oral hygiene, effervescent mouthwash tablet, antimicrobial study, Curcumin, Azadirachta indica.


Parexel International India Pvt. Ltd., Mohali 140308, Punjab, Department of Pharmaceutics, Rayat Bahra Institute of Pharmacy, Hoshiarpur 146104, Punjab, Department of Pharmaceutics, Northern Institute of Pharmacy & Research, Alwar, Rajasthan 301028, Department of Pharmaceutics, Indo Soviet Friendship College of Pharmacy, Moga 142001, Punjab, Department of R & D, Ananta Medicare Limited, Sriganganagar, Rajasthan 335002, Department of Pharmacy Practice, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207

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