Submit Manuscript  

Article Details


Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery

[ Vol. 13 , Issue. 4 ]

Author(s):

Srividya Gorantla, Tejashree Waghule, Vamshi Krishna Rapalli, Prem Prakash Singh, Sunil Kumar Dubey, Ranendra Narayan Saha and Gautam Singhvi *   Pages 291 - 300 ( 10 )

Abstract:


Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and others including light, thrombin, pressure, antigen, and glucose-responsive. Incorporation of nanocarriers with these smart stimuli-responsive drug delivery systems that can extend the duration of action by increasing ocular bioavailability and reducing the dosing frequency. This review will focus on the hydrogel drug delivery systems highlighting the gelling mechanisms and emerging stimuli-responsive hydrogels from preformed gels, nanogels, and the role of advanced 3D printed hydrogels in vision-threatening diseases like age-related macular degeneration and retinitis pigmentosa. It also provides insight into the limitations of hydrogels along with the safety and biocompatibility of the hydrogel drug delivery systems.

Keywords:

Ophthalmic drug delivery, hydrogel, stimuli-responsive, nanogel, vision-threatening diseases, macular degeneration.

Affiliation:

Department of Pharmacy, Birla Institute of Technology & Science (BITS), Pilani, Pilani Campus, Rajasthan 333031, Department of Pharmacy, Birla Institute of Technology & Science (BITS), Pilani, Pilani Campus, Rajasthan 333031, Department of Pharmacy, Birla Institute of Technology & Science (BITS), Pilani, Pilani Campus, Rajasthan 333031, Formulation development, Slayback Pharma India LLP, Hyderabad, Telangana-500072, Department of Pharmacy, Birla Institute of Technology & Science (BITS), Pilani, Pilani Campus, Rajasthan 333031, Birla Institute of Technology & Science (BITS) - Pilani, Dubai Campus, Department of Pharmacy, Birla Institute of Technology & Science (BITS), Pilani, Pilani Campus, Rajasthan 333031

Graphical Abstract:



Read Full-Text article