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Bilayer Tablet Based Chronotherapeutics in the Management of Nocturnal Asthma: An Overview

[ Vol. 13 , Issue. 2 ]


Sourav Thakur, Bhupendra Singh, Vijay Mishra*, Nishika Yadav, Namita Giri, Pardeep Sharma, Ankit Saini and Lavi K. Garg   Pages 74 - 82 ( 9 )


Background: Asthma is a common ailment with a larger circadian difference. Nocturnal Asthma (NA) is an inconstant exacerbation of asthmatic condition related to the rise in warning sign during the night time and there is a need for its treatment addressing air route alertness and decline in lung functions. These symptoms are linked to sleep or known as circadian events. Chronotherapeutics is a management system based on an in-vivo drug accessibility programmed to check the rhythms of ailment in a direction to improve the therapeutic outcomes by suppressing the side effects. This review aims to provide an overview of NA, chronotherapeutics for the treatment of NA, bilayer tablets, and advanced techniques involved in the fabrication of bilayer tablets. The review also discusses some of the related patents.

Methods: Relevant literature about the latest developments and updated information related to NA, chronotherapeutics and bilayer tablets has been very widely searched on different biomedical literature programs such as Google, Web of Science, PubMed portals, etc. Bilayer tablet mediated chronotherapy has gained significant attention and consideration as it is developed and fabricated based on the body’s circadian rhythm. Bilayer tablets can deliver the bioactive compounds at an appropriate time, place as well as amount and site.

Results: Available literature advocated that the bilayer matrix tablet containing a single drug in the sustained release film and fast releasing film, may be beneficial for the chronic diseases like asthma, migraine, diabetes, hypertension and inflammation which usually require immediate as well as maintained therapeutic effect.

Conclusion: The application of nanotechnology in the arena of medicine will transform the diagnosis and treatment strategies of a wide range of diseases in the upcoming years. The findings of this review confirm the importance of bilayer tablet based chronotherapy in nocturnal asthma.


Asthma, circadian rhythm, chronotherapeutics, bilayer tablet, migraine, hypertension.


Abbott Healthcare Private Limited, Baddi (Himachal Pradesh), Abhilashi College of Pharmacy, Ner-Chowk, Mandi (Himachal Pradesh), School of Pharmaceutical Sciences, Lovely Professional University, Phagwara (Punjab), School of Pharmaceutical Sciences, Lovely Professional University, Phagwara (Punjab), School of Pharmacy, Ferris State University, Big Rapids, Michigan 49307, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara (Punjab), Bhardwaj India Private Limited, New Delhi, Abbott Healthcare Private Limited, Baddi (Himachal Pradesh)

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