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Formulation, In-Vitro and Ex-Vivo Evaluation of Tretinoin Loaded Cubosomal Gel for the Treatment of Acne

[ Vol. 12 , Issue. 2 ]

Author(s):

Shruti Sureka, Gaurav Gupta*, Mohit Agarwal, Anurag Mishra, Santosh K. Singh, Ravindra P. Singh, Sushil K. Sah, Terezinha de Jesus A. Pinto and Kamal Dua   Pages 121 - 129 ( 9 )

Abstract:


Objective: The current work was attempted to formulate and evaluate the topical sustained release delivery systems called cubosomes containing Tretinoin for the acne treatment. The recent patents on various formulations of tretinoin (EP0408370A2) helped in selecting a new formulation and evaluation.

Methods: Tretinoin loaded cubosomes were prepared by bottom-up technique, using varying the concentration of lipid and surfactant and keeping the drug concentration constant, a total of nine formulations of tretinoin was developed. These preparations were evaluated for surface charge, particle size, particle morphology, encapsulation efficiency, in-vivo and in-vitro release studies of gel enriched with cubosome dispersion. Finally, the stability studies of cubosomal gel were performed on optimized formulations.

Results: Significant result were obtained with tretinoin formulation as the drug is lipophilic, so it gives more depot effect on the epidermis and good retention property. The data obtained from the formulations showed that formulation TCF-5 was the optimized formulation which exhibited better drug release and entrapment efficiency.

Conclusion: It can be concluded that cubosomes offer benefits of quick onset as well as the maximal release of drug with fewer side effects. Thus, cubosomes represent a capable transporter having the property to sustain the release of drug, potential to localize the drug in the skin with a possible clinical application for acne vulgaris treatment due to cubosome depot effect on the epidermis.

Keywords:

Cubosome, tretinoin, topical, monoglyceride, poloxamer-407, biodegradability.

Affiliation:

Department of Pharmaceutics, Smriti College of Pharmaceutical Education, Dewas Naka, Indore, Madhya Pradesh 452010, Birat Medical College, Biratnagar, School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur 302017, School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur 302017, School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur 302017, School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur 302017, Birat Medical College, Biratnagar, Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, São Paulo, Rua Professor Lineu Prestes, 05508–000, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh 173 229

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