Ashwathanarayana Madhu, Gaurav Gupta*, Bharati Arali, Dinesh K. Chellappan and Kamal Dua Pages 36 - 41 ( 6 )
Aims and Background: Psychosis is a neurological disorder, which is usually defined as the "loss of contact with reality." As medicine ‘Hemidesmusindicus’ holds a reputed place in all systems of medicine in India. It is given in the form of infusion, fine particles, or syrup. It is also a component of several medicinal preparations. The present research work is pertaining to find out an anti-psychotic activity of an aqueous root extract of Hemidesmusindicus- a time bound study in rats.
Methods: In the present study, the dried roots of Hemidesmusindicus were crushed to a coarse powder and extracted with water under reflux for 36 hours to obtain the aqueous extract of roots of Hemidesmusindicus (AERHI). The extract was reconstituted in 2% aqueous tragacanth just before use and administered orally at a dose 0f 100 mg/kg, 300 mg/kg and 500 mg/kg. In a single dose study, the parameters were assessed after oral administration of the single dose of the AERHI, whereas in a multiple dose study, the animals daily received the suitable oral dose of the AERHI for a period of 30 days. The parameters were assessed on the 15th and 30th day. The antipsychotic activity was screened using Apomorphine induced Stereotyped behavior in rats and Haloperidol induced catalepsy models were used. In Apomorphine induced Stereotyped behavior inhibition of the Stereotyped behavior was considered to be anti-psychotic activity and in Haloperidol induced catalepsy, we observed whether the AERHI potentate or attenuate the catalepsy in rats.
Results: In this study, the extract of Hemidesmusindicus significantly inhibited the stereotyped behavior induced by apomorphine in rats and also potentiate the catalepsy induced by haloperidol, thereby showing its anti-psychotic activity.
Conclusion: All these observations imply that Hemidesmusindicus extract possesses anti-psychotic activity in experimental animals.
Catalepsy, stereotyped behavior, anti-psychotic, Hemidesmusindicus, aqueous root extract, catalepsy.
East West College of Pharmacy, Off Magadi Road, Bangalore – 560091, School of Pharmacy, Jaipur National University, Delhi-Agra bypass, Jagatpura 302017, Jaipur, East West College of Pharmacy, Off Magadi Road, Bangalore – 560091, School of Pharmacy, International Medical University, Kuala Lumpur 57000, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW 2308