Suryakanta Swain, Sarwar Beg and Sitty M. Babu Pages 59 - 71 ( 13 )
Researchers are facing challenges to develop robust formulation and to enhance the bioavailability of poorly water-soluble drugs towards clinical applications. The development of new drug molecule alone is not adequate to assure ample pharmacotherapy of various diseases. Considerable results obtained from in vitro studies are not supported by in vivo data due to inadequate plasma drug concentrations. This may occur due to limited drug solubility and absorption. To resolve these problems, development of new drug delivery systems will be a promising approach. One of the promising pharmaceutical strategies is the use of lipospheres drug delivery system to deliver the poorly water-soluble drugs. Therefore, the present review described the methodology for manufacturing of lipospheres and factors influencing the formulation to deliver the drugs to the targeted site. Apart from that, this review also enlisted briefly the various applications of liposphers in medical and biomedical fields and critically discussed the recent patent system.
Applications, delivery approaches, formulation techniques, nanolipospheres, recent patents.
Department of Pharmaceutics, Southern Institute of Medical Sciences, College of Pharmacy, SIMS Group of Institutions, Mangaladas Nagar, Vijayawada Road, Guntur-522 001, Andhra Pradesh, India.